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In addition, non-neuronal cells residing in both the central nervous system (CNS) and peripheral nervous system (PNS) called glial cells, and among them mainly astrocytes, microglia, and oligodendrocytes provide essential metabolic and functional support to neurons, contributing to their plasticity [238,239,240,241]

Kannan and colleagues demonstrated the existence of Na + -dependent and Na + -independent GSH transporters in an in vitro BBB model by using human cerebral microvascular endothelial cells (HCEC)